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Nrf2 is a transcription factor that regulates several enzymes involved in cellular stress responses, some of which include superoxide dismutase catalase, glutathione peroxidase, and glutathione reductase 5

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These factors also lead to deficiencies in magnesium, vitamin C, and vitamin B6, which are important for neutralizing bad estrogen metabolites in the liver

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Together, these peptides present complementary effects suggesting possible additive interactions in models of chronic inflammation and delayed healing