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While gastrointestinal side effects are more common, its essential to be vigilant for severe side effects like pancreatitis, kidney problems, or severe allergic reactions

In the basal state PNPLA2 has weak hydrolytic activity which is greatly increased by the co-lipase alpha/beta hydrolase domain-containing protein 5 (ABHD5, also known as CGI-58) by greater than 20-fold (30)

+ Insulin, HbA1c,7/ Conclusion Microdosing GLP-1-RAs represents a promising approach to leverage their potential longevity benefits while minimizing risks

Post-cholecystectomy physiology changes bile acid regulation, which may affect gastrointestinal tolerance to GLP-1 agents and requires individualized evaluation