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As cystatin C deposition is systemic in HCCAA patients, it is possible that precipitation and accumulation of amyloid in the brain and blood vessels is reduced when reduction is observed in the skin

doi: 10.3389/fendo.2023.1182049 20 NielsenCHBrixTHLeslieRGQHegedsL

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Gene 858:147167 Benson BC, Shaw PJ, Azzouz M et al (2021) Proteinopathies as hallmarks of impaired gene expression, proteostasis and mitochondrial function in amyotrophic lateral sclerosis

References 1.Weibel S., Menard O., Ionita A., Boumendjel M., Cabelguen C., Kraemer C., Micoulaud-Franchi J.-A., Bioulac S., Perroud N., Sauvaget A., et al