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Patients on semaglutide typically reduce daily caloric intake by 500-800 calories without conscious restriction, according to ad libitum food intake studies conducted during the STEP trial program (Wilding et al., New England Journal of Medicine, 2021)

"This medication is not a shortcut that replaces effort," she stressed

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For example, in one cohort study of 125,474 patients (without type 2 diabetes) who initiated GLP-1s, 46.5% discontinued use within one year