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Due to this androgen-dependent alteration in insulin sensitivity, women with PCOS frequently exhibit compensatory hyperinsulinemia

10.1038/mp.2012.141 23 HarastaA

Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants