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Coya said the trial met its primary endpoint for safety and secondary endpoint for regulatory T cell (Treg) cell population enhancement, with no off-target effects on T effector lymphocytes, providing further evidence of target engagement in 22 patients dosed with five days of LD IL-2 (106 IU/day) or placebo every four weeks for 21 weeks

CagriSema is not FDA-approved and not available outside clinical trials

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The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis

10.1007/s10620-017-4470-9 17 CaiW.SakaguchiM.KleinriddersA.Gonzalez-Del PinoG.DreyfussJ