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Case reports exist of palpitations and faster heart rate, and postmarketing data include rare arrhythmia reports, so clinicians weigh pulse changes against cardiovascular risk reduction seen in many trial populations

Semaglutide's weight loss effects come from its action on GLP-1 receptors in the brain and gut

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GLP-1 Receptors Exist Throughout the Body Although GLP-1 medications work in the pancreas to regulate insulin and glucagon, GLP-1 receptors are widely distributed in other areas of the body, including the brain, cardiovascular system, immune system, gut, and kidneys, says Diana Isaacs, PharmD, CDCES, an endocrine clinical pharmacy specialist in the Endocrine and Metabolism Institute at Cleveland Clinic in Ohio