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They act on the brain to reduce hunger and increase feelings of fullness

Short-acting GLP-1 agonists like exenatide (taken twice daily) may produce more immediate effects on post-meal glucose levels, whilst longer-acting weekly formulations such as semaglutide or dulaglutide provide more sustained action but may take longer to reach steady-state concentrations in the body

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J Neurol Neurosurg Psychiatry (2020) 91(8):795808

No changes in plasma cholesterol levels were observed for any of the treatments (Fig