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Metformin, a first-line diabetes medication, interferes with B12 absorption in the terminal ileum through mechanisms involving calcium-dependent membrane action and bacterial overgrowth
Consequently, cGAS evades p62-mediated autophagic degradation and can stimulate type I IFN signaling after viral infection (156)
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The small B12 injections show promising potential as they may serve as a hidden approach to reaching weight loss targets through their effects on energy metabolism
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