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Globus sensation can last a few hours, several days, or even longer depending on the underlying cause

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Accordingly, alanine mutagenesis of TM7 residues influenced both GLP-1 and oxyntomodulin affinity, but there was a larger effect on oxyntomodulin, consistent with its stronger interactions, however, interestingly these residues were more important for GLP-1-mediated cAMP production (Supplemental Figures 9-10)