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Regression of paracetamol provoked hepatotoxicity and nephrotoxicity by spirulina, butylated hydroxytoluene and cilostazol in adult Male albino rats: modulation of inflammatory, oxidative stress and apoptotic biomarkers

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Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, et al

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The authors presented a case study of how literature data on fish ecotoxicity studies can be used in ERAs, offering considerations in the use of literature studies/data and embracing the 3Rs principles as intended in the 2024 EMA Guideline