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The logic is that bupropion + naltrexone (Contrave) addresses reward-driven eating and appetite, while topiramate independently suppresses cravings through a different brain mechanism

"Ultimately, we believe that the decision to start, stop, or continue a GLP-1 should be made in the medical home -- between the patient and their primary care physician." Shao said Omada Health's role as an "in-between-visit healthcare provider" supplements the existing healthcare system rather than replace it

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Additionally, Wegovy can delay gastric emptying, which may theoretically affect the absorption of some oral medications, although this is not specifically noted as a concern with sertraline in clinical guidance

Clinical and preclinical data do not guarantee future approval