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If your blood vessels are narrower or if your heart is not pumping as effectively, it can make it harder for your body to keep warm

Specifically, we dissect how baseline microbial signatures correlate with differential efficacy, while critically assessing clinical confounding factors, such as metformin co-treatment and dietary shifts, and the methodological limitations that currently hinder the translation of microbiome profiling into precision endocrinology

Spironolactone is commonly used in this setting because it targets androgen-driven changes rather than directly targeting estrogen levels

And so if GLP-1 can keep those people alive longer, the back end of keeping people on dialysis longer may actually be more of a tailwind to volume than the slowdown on the front end, if that makes sense

Moreover, it improves triglyceride clearance and the sensitivity of adipose tissue to insulin, which may prevent ectopic fat deposition [16]