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Research has confirmed no significant effects on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no immunogenicity with no anti-AOD-9604 antibodies detected in any participants

What is largely agreed on, however, is that B12 deficiency can reduce energy levels and therefore make it harder to stay active and maintain a healthy weight

Inadequate vitamin B12 affects the nervous system

No single or dual-agonist compound can replicate the combined effects on appetite regulation, insulin secretion, lipolysis, and thermogenesis that retatrutide produces in research settings

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