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The prototypic redox-based signaling mechanism

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CTLA-4 is an inhibitory receptor induced in effector T cells upon activation and constitutively expressed by Tregs

Furthermore, in sensitive strain treated with FLC, total glutathione is markedly decreased and this evidence may be explained considering an efflux from the cell

This activation inhibits intracellular serine/threonine kinases, like JNK, which in turn reduces insulin receptor substrate (IRS)-1 serine phosphorylation, a major contributor to insulin resistance, and decreases atherosclerosis