triple-hormone-receptor agonist retatrutide for obesity Original Article: Triple–Hormone-Receptor — A Phase 2 Trial https://t.co/jNL1GNnHPT #ADA23 Retatrutide—A Game Changer in Obesity

The traditional classification of microglial phenotypes into binary M1 (pro-inflammatory) and M2 (anti-inflammatory/neuroprotective) categories has provided a useful conceptual framework, though it is increasingly recognized as an oversimplification of their functional diversity (Figure 5)

Tirzepatide is a dual GLP-1 + GIP receptor agonist

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And they talk through many of the same molecular messengers