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Processed foods, excessive sugar, and refined carbohydrates promote inflammation and insulin resistance that counteract the medications metabolic benefits

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However, in mice at TN, elevated lipid oxidation occurred later during the transition from the rapid to the gradual weight loss period and abruptly ended during the transition into the weight maintenance period, whereas carbohydrate oxidation was significantly lower during the rapid weight loss period and increased during the gradual weight loss period ( Figure 7C-F )