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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

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The Lasker Award for Clinical Medical Research recognized Habener (Massachusetts General Hospital) and Mojsov (Rockefeller University) for discerning the physiologically active form of the hormone (GLP-1)

A common approach involves 5-6 days per week dosing with 1-2 rest days

The right patient, in 2026, is increasingly someone who has already named her PCOS subtype, addressed the engine of her symptoms (insulin or adrenal or inflammatory), and is using spironolactone as the targeted skin-and-hair lever rather than as a first-line guess