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Notably, serious adverse events and discontinuations due to adverse events were similar between the semaglutide and placebo groups, and no new liver-specific safety signals emerged [7]

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showed, for example, that CNS leptin administration increases survival in an animal model of sepsis, and this effect was not a consequence of leptin-induced modulation of the HPA axis since plasma levels of corticosterone were not altered in leptin treated animals [44]

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Recommended testing schedule Baseline (before starting): Complete metabolic panel, CBC, lipid panel, HbA1c (even if not diabetic), B12, folate, vitamin D, thyroid panel, and fasting insulin