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GHK-Cu was discovered in 1973 and has been found to stimulate dermal fibroblasts in the dermis and upregulate the production of collagen, elastin, and glycosaminoglycanthe main components of the intercellular matrix of tissues such as the skin [4]

Lactate dehydrogenase activity staining demonstrates time-dependent immune cell infiltration in human ex-vivo burn-injured skin

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Abbreviations VLCKDs: Very low-calorie ketogenic diets SIE: Italian Society of Endocrinology EASO: European Association for the Study of Obesity KDs: Ketogenic diets BMI: Body mass index sHypo: Subclinical hypothyroidism TSH: Thyroid-stimulating hormone fT3: Free triiodothyronine T4: Thyroxine TT4: Total T4 fT4: Free T4 kcal: Kilocalories LCD: Low-calorie diet L-T4: Levothyroxine TRH: Thyrotropin-releasing hormone TPO: Thyroid peroxidase GLUT4: Glucose transporter type 4 References Papers of particular interest, published recently, have been highlighted as: Of importance Of major importance Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Salzano C, Savastano S, Colao A