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Our findings suggest that metformin has a greater predicted neuroprotective impact compared to 38 other DM2 DMTs, including semaglutide, that target the DM2-AD comorbidity network, primarily by engaging key metabolic and neuroinflammatory pathways and by indirectly modulating viral-associated mechanisms relevant to AD pathology

In our study, the OB GLP-1/GLP-1R neuronal circuit appears to control insulin secretion via the SNS

These were generally dose-related and reversible