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When the cellular antioxidant system fails to neutralize excess ROS, oxidative stress ensues, leading to RGCs degeneration and optic nerve damage (124)

In the acute phase of stroke, targeted clearance or inhibition of neutrophil infiltrationvia delivery of anti-Ly6G antibodies or blockade of CXC chemokine receptor 2 (CXCR2) and very late antigen-4 (VLA-4)can significantly improve neurological deficits and reduce infarct volume (78)

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