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N -methyl-D-aspartate (NMDA)-DR heteromers NMDA-D1R Heteromers Heteromers, consist of D1R and NMDAR, increase the phosphorylation of NR1 and NR2B subunits, surface insertion of NR2B, and NMDA-triggered Ca2+ upregulation via cAMP/PKA/RACK1-mediated Fyn activation (67, 68), and PKC/CAK/Src signaling (69), thus enhancing NMDAR-mediated currents