is wegovy the same as tirzepatide Outperforms in Reducing Major Adverse Cardiovascular Events Which Weight-Loss Drug Is Better:

China Patent Application CN104286415 (A) Xu Z, Yang X, Hang B, Chen B, Li J, Huang L (2016) Mutant gene of gshF genes of Streptococcus agalactiae and application thereof

10.1038/s41419-020-03194-2 100

Nitric oxide keeps your blood pressure level within a normal range by signaling blood vessel muscles to relax, expand and let blood through, while also preventing clots and plaque from forming

Black Stool Possible cause: Consuming dark-coloured foods (e.g., black licorice, blueberries, dark chocolate) Taking iron supplements or bismuth subsalicylate (e.g., Kaopectate, Pepto-Bismol) Black, tarry stool (like tar) may indicate upper gastrointestinal bleeding (e.g., stomach ulcers or oesophageal varices) When to be concerned: If unexplained by diet or medication, seek medical attention immediately

FDA-APPROVED INDICATIONS Type 2 diabetes As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus Limitations of use: has not been studied in patients with a history of pancreatitis TYPE 2 DIABETES RCT SURPASS-2 trial - Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes, NEJM (2021) [PubMed abstract] The SURPASS-2 trial enrolled 1879 adults with type 2 diabetes who were inadequately controlled with metformin at a dose of at least 1500 mg per day Main inclusion criteria Age 18 years T2DM uncontrolled with metformin at 1500 mg/day A1C of 7 - 10.5% BMI 25 and stable for 3 months Main exclusion criteria Type 1 diabetes GFR 50 ng/L