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doi: 10.1016/j.theriogenology.2018.03.035, 176

Past performance is not indicative of future returns

Minges KE, Whittemore R, Weinzimer SA, Irwin ML, Redeker NS, Grey M

An example is cyclopenthiazide

C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter