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T1DM is typically diagnosed early in life, which raises concerns about its long-term impact on reproductive health, as early-onset metabolic disturbances may coincide with critical periods of testicular development and maturation

These effects occurred without inducing aversive states or altering metabolic rate, suggesting selective action on appetite and satiety circuits

Thymoquinone attenuates doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4

[PubMed: 26853157] 50

Those who are concerned or particularly sensitive can request additional pre-injection numbing injections with lidocaine or can use ice prior to injection to numb the treatment area (avoiding the initial pin-prick of Vollure)