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Chapter Outline G6PD IN RED BLOOD CELL METABOLISM Structure and Biochemistry of G6PD Features of G6PD in Red Blood Cells Molecular Basis of G6PD Deficiency CLINICAL MANIFESTATIONS OF G6PD DEFICIENCY LABORATORY DIAGNOSIS OF G6PD DEFICIENCY GENOTYPE-PHENOTYPE CORRELATIONS G6PD DEFICIENCY AND PREVENTIVE MEDICINE G6PD DEFICIENCY IN NONERYTHROID CELLS G6PD DEFICIENCY COEXISTING WITH OTHER DISORDERS Most hemolytic anemias can be categorized, at least at first approximation, as being either inherited or acquired as a result of either intracorpuscular or extracorpuscular causes

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Once released in the body, it attaches to the pituitary gland receptors

By preventing nicotinamide methylation, the compound increases intracellular NAD+ availability, which in turn activates sirtuins and other NAD+-dependent enzymes critical for metabolic homeostasis