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The study employed advanced analytical methods, such as UPLC-MS for plasma samples and HPLC with fluorometric detection for erythrocytes, to measure GSH and related compounds accurately, given their low concentrations

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Clin Pharmacokinet 2012;51:553-72

The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

As a result, ferroptosis is mainly induced trough the disruption of the aforementioned endogenous ferroptosis inhibitory pathways