In fact, similar observations have been made with amylopectin sulfate, a branched polysaccharide with -1,6 and -1,4-glucosidic links, which has been shown to induce lesions, but not induce tumor formation, in rats (Ishioka and Kuwabara 1986 Ishioka, T., and N
To put that into perspective, previous generations of medications typically achieved between 15% and 20% weight loss in similar timeframes
Experimental protocols often involve comparing the effects of Cagrilintide alone, a GLP-1 agonist alone, and the combination of both in well-controlled animal cohorts
You dont have to guess
Massachusetts General Brigham researchers found that GLP-1s can reduce muscle and bone tissue, leading to ketosis (loss of muscle mass), which is particularly dangerous for older adults