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Different pathological glial phenotypes may co-exist in the same pathological process or can be associated with different stages of the disease or disorder

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This pathway primarily modulates GH pulse frequency and timing, acting at both hypothalamic and pituitary levels

308 Experimentally-induced depletion or attenuation of reactive astroglia markedly exacerbates the clinical progression, spread of inflammation and tissue loss in EAE during the induction phases of the disorder, 81,309,310 whereas similarly induced depletion of proliferating reactive astrocytes at later times during the progressive phase ameliorates disease, and this amelioration is at least in part due to removal of astrocyte Ccl2 production

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