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a mucin-type O-glycan core found in normal epithelial tissue and downregulated in many carcinomas
in which the sugar hydroxyls are protected as acetate esters
C95H151N17O64 / 2371
C18H25NO13 / 463
Synthetic MUC-4 (Tn) glycopeptide
GA121000: Fmoc-Ser(GalNAc(Ac)3-α-D)-OH Pack Size:100 mg a mucin-type O-glycan core foundC32H36N2O13 656. 63 An Fmoc protected L serine building block carrying an D GalNAc residue, designed for solid phase peptide synthesis (SPPS) of glycopeptides. The N Fmoc group is removed under standard base conditions (piperidine) during chain elongation, while the free carboxylic acid is available for coupling to the growing resin bound peptide. The sugar hydroxyl groups are protected as three acetate esters (Ac3), which keep the glycan inert during
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