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Immediate medical attention is warranted for symptoms suggesting serious complications: signs of pancreatitis (severe upper abdominal pain radiating to the back, nausea, vomiting), symptoms of kidney problems (significant changes in urination, swelling in legs or feet), irregular heartbeat or chest pain (which could indicate electrolyte imbalances), or signs of severe dehydration (confusion, rapid heartbeat, fainting)

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Registry data from childhood GH exposure suggest higher CV risk, whereas adult replacement therapy appears neutral at physiological doses [59,60,61,62,63,64]