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Yamakoshi, J., Sano, A., Tokutake, S., Saito, M., Kikuchi, M., Kubota, Y., Kawachi, Y., & Otsuka, F

Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility

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Since an IGF-1R construct, in which the tyrosine at position 1136 was replaced by a phenylalanine, also led to a strong inhibition of phosphorylated Akt in transfected cells, it was suggested that this mechanism may be responsible for the apoptotic effect of PPP (Vasilcanu et al, 2004)

Phytomedicine 80 , 153370 (2021)