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475 Currently, one of the most effective strategies for inhibiting Rho GTPase activation involves the use of small molecule inhibitors, such as Rhosin, 476 which target the GEF binding surface on Rho GTPase to prevent its activation, inhibiting platelet activation, ROS production, platelet diffusion, secretion, and aggregation

Research should identify the reversible critical point of metabolic memory to define optimal intervention timing

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GLP-1 receptor agonists are synthetic analogues that mimic and extend these effects