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Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

Proc Natl Acad Sci U S A, 2016

doi: 10.1016/j.exer.2020.108292 164 ChaudharyKPromsoteWAnanthSVeeranan-KarmegamRTawfikAArjunanPet al

The gene expression of Gpx4 , one of the most important antioxidant enzymes and the key ferroptosis regulator, is increased in the brain of AD mouse model compared to WT [16]