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Therapeuticresearch.com

J Pharmacol Exp Ther 351:390402

Payers are fronting high acquisition costs for these biologics, but the value proposition evaporates if the patient drops off before reaching the maintenance phase

Furthermore, most preclinical studies have used short-term high-glucose or db/db mouse models, which fail to recapitulate the chronic, progressive nature of human DN (e.g., long-term fibrosis and comorbidity-associated complications)