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In CRC, the p53-induced gene TIGAR (TP53-induced glycolysis and apoptosis regulator) has been identified as an effective inhibitor of the EMP, redirecting energy utilization towards the PPP [70]

Virz GM, Morisi N, Marturano D, Milan Manani S, Tantillo I, Ronco C, et al

The best results are obtained when combined with a healthy diet and regular exercise

GLP-1 medications require follow-up

(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle