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University of California Davis Health System

Tirzepatide binds GLP-1 and GIP receptors with nanomolar affinity

oleifera leaf extract SDS Sodium dodecyl sulfate MSP Moringa bud powder DPPH 2,2-Diphenyl-1-picrylhydrazyl ABTS 2,2-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) LPO Lactoperoxidase AGEs Advanced glycation end-products Bax BCL 2 -associated X protein BCl 2 B-Cell lymphoma-2 ACE Angiotensin I-converting enzyme IL-3 Interleukin-3 STAT5 Signal Transducer and Activator of Transcription 5 UVB Ultraviolet radiation b MMP-1 Matrix metalloproteinase 1 MMP-3 Matrix metalloproteinase 3 MMP-9 Matrix metalloproteinase 9 TNF- Tumor necrosis factors- IAVS Influenza A viruses GSK-3 antibody Glycogen synthase kinase-3 DDPH 2,2-Diphenyl-1-picrylhydrazyl ORAC Oxygen Radical Absorption Capacity TLR4 Toll-like receptor 4 T-47D Human breast ductal carcinoma cells CD31 Platelet endothelial cell adhesion molecule-1 Smac Second mitochondria-derived activator of caspases HSP 70 Heat shock protein 70 Skp2 S-Phase kinase-associated protein 2 Fbw7 F-Box and WD repeat domain-containing7 INF-B Nuclear factor kappa-B inhibitor ERK Extracellular-signal-regulated kinase TGF- Transforming growth factor beta IFN-y Interferon-gamma Th2 T-Helper cell type 2 NAFLD Non-alcoholic fatty liver disease HFD Histone fold domain p 22phox Cytochrome b-245, alpha polypeptide p 47phox Phospho-Ser359 RUNX2 Runt-related transcription factor 2 COL-1 Collagentypel 1 Author contributions Xinyue Su, Guanzheng Lu, Liang Ye Maomao Zhu and Xinming Yu collected and analysed the literature data

Bonfanti et al