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Koob, ad libitum fed rats, if the chow is available as the only source of calories (Dickson et al., ad libitum fed rats compared with those effective in the VTA, indicating perhaps that NAc is somewhat less sensitive to the intake reducing effects of EX4 (Alhadeff et al., Together, these data support a role for mesolimbic GLP-1Rs in the regulation of food intake, irrespective of the macronutrient composition of the food

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Oral semaglutide offers an alternative for individuals seeking a non-injectable option while maintaining therapeutic intent under medical guidance