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Liraglutide was also associated with a modest increase in gallstone incidence, especially with rapid weight loss [11]

Wegovys prescribing information also includes a boxed warning and similar contraindication language

Advertisement With this dual agonism, tirzepatide has demonstrated the largest weight loss in a randomized trial of any medication for obesity/overweight to date, with its highest dose achieving a 22.5% reduction relative to placebo at 72 weeks in the phase 3 SURMOUNT-1 trial ( N Engl J Med

The higher real-world figure reflects what happens when medication is combined with ongoing clinical monitoring, behavioural coaching, and dose adjustment over time

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