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Diacetyl and related diketones Diacetyl and similar diketones are linked to respiratory toxicity in occupational inhalation studies

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Other investigators reported that mice deficient in MMP ( MMP*/* ) that had a single exposure to the whole smoke of four 2R1 reference cigarettes did not show the same early elevations in lavage neutrophils, desmosine, or hydroxyproline that are seen in mice with normal levels of MMP activity ( MMP*+/*+ ) (Churg et al