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producing high-avidity binding that substantially exceeds the affinity of monovalent GalNAc ligands and closely mimics the geometry of clinically validated Tri-GalNAc targeting moieties used in approved GalNAc-siRNA therapeutics
a model β-glucan building block for glycopeptide synthesis and glycosidase studies
Synthetic MUC-1 (Tn) glycopeptide
R) / α-Tocopherol-d3 Acetate
C92H146N22O34S / 2136
GP100130: Biotin-PDPN(74-85-Gly-Lys)-Tn(77) Mouse Pack Size:0.5 mg producing high-avidity binding that substantiallyC84H141N23O29S 1969. 2 PDPN (UniProt ID Q62011) synthetic Glyco dodecapeptide epitope (Glu74 Ser85 Gly Lys) that is present within the extracellular domain of the glycoprotein podoplanin. The glycopeptide fragment has tumor associated cancer antigen Tn at Thr77. Biotin was appended on the amine of the C terminal lysine. The posttranslational GalNAc modification is expressed by an aggressive fibrosarcoma, Ag104A, and is bound by Anti Tn Antigen
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