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3.2.3 Study on the role of glutathione Glutathione (GSH), as the main intracellular antioxidant, is important in maintain the oxidative-reductive balance within cells

Selenoprotein P expression is controlled through interaction of the coactivator PGC-1 with FoxO1a and hepatocyte nuclear factor 4 transcription factors

Furthermore, glucose-6-phosphate derived from glycolysis can be diverted into branching metabolic pathways, such as the pentose phosphate pathway (PPP), where it is partially oxidized to generate NADPH (28)

Both decreases and increases in reduced glutathione (GSH) and glutathione disulfide (GSSG) levels were reported in fibroblasts undergoing senescence, including replicative senescence (RS), oncogene-induced senescence (OIS), and therapy-induced senescence (TIS) (Quijano et al., 2012

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Mischkowski D., Crocker J., Way B.M