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As the condition advances, the open space in the spinal canal continues to decrease, usually from degenerative spinal changes like: Thickened spinal ligaments Weakened, bulging, or herniated spinal discs Arthritic facet joints and/or spinal bone spurs Eventually, spinal stenosis can lead to nerve impingement as the spinal canal presses on nearby nerves

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when properly functionalized with glutathione corona carrying the dansyl chromophore (DG-AuNPs) they spontaneously produce aggregates with enhanced response to the pulsed excitation in the NIR region where the chromophore acts as antenna