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The SURPASS clinical trial program demonstrated that nausea, diarrhea, vomiting, constipation, dyspepsia, and abdominal pain are the predominant GI complaints

[4] [5] These symptoms result from delayed gastric emptying and direct effects on the gastrointestinal tract

Nez R, Sancho-Martnez SM, Novoa JML, Lpez-Hernndez FJ (2010) Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies

By connecting the hindbrain to the central amygdala and dopamine neurons, these drugs effectively turn down the volume on the desire for high-calorie foods

Ethics declarations Ethical Approval This study was performed in line with the principles of the Declaration of Helsinki