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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

Digestive diseases: such diseases as Crohn's or coeliac hamper the absorption of B12 in the ileum

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The take-away : Acetyl-l-carnitine tops our list because it is one of the most promising supplements for depression