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A small percentage of mice with only one copy of the GPx-1 allele and complete deficiency of GPx-2 develop mild ileocolitis (GPx-1 +/ GPx-2 / ), whereas a single copy of the GPx-2 gene (GPx-1 / GPx-2 +/ ) protects against inflammation, leading to the suggestion that GPx-2 has a greater protective effect in the intestine than GPx-1 (114), although an earlier study reported that one copy of either of these GPx genes was sufficient to prevent the development of intestinal cancer (72)
However, biodistribution and tissue retention effects reported in preclinical studies imply that functional/biological effects can persist longer than plasma exposure alone would predict
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10.1111/nph.12304 25 ChisholmS
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