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While multiple randomized controlled trials (RCTs) have confirmed the short-term efficacy and safety of GLP-1 RAs, the long-term outcomes, particularly regarding sustained weight loss, weight regain, and safety profiles, remain areas of active investigation [6]

doi: 10.1016/j.molmet.2015.07.008 [DOI] [PMC free article] [PubMed] [Google Scholar] 71

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The increases in MAP and HR responses to intravenous infusion of GLP-1 were not significantly different between Sham and HF rats (Fig