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Chapter 3: Pretrial Proceedings 3.1 Discovery Both parties exchange information and evidence relevant to the case

These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation.368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption.369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

157 Ingesting clear fluids reduces the acidity of gastric contents still present during fasting, thereby decreasing the potential harm from aspiration

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