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Coculturing glioblastoma spheroids with GBM spheroid and hCEMC/D3 cells has revealed a specific role of IL-8 in promoting tumor growth and tumor migration (McCoy et al., 2019)

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However, they are still important for many biological functions

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Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use